Beklemishev Anatoly Borisovich (he was born in 1946)
Doctor of Biological Sciences, Professor
Anatoly Borisovich Beklemishev, a graduate of the biological faculty of KazGU, began his scientific career in 1969 in the laboratory of protein and nucleic acids, Murat Abenovich Aitkhozhin, which was organized in the same year at the Institute of botany of Academy of Sciences Kazakh SSR. There he went from senior laboratory assistant to senior researcher and defended his thesis on the specialty “Biochemistry” under the leadership of M.A. Aitkhozhin in 1974. His research interests in this period of time were related to the study of the regulation of protein biosynthesis at the translation level. He was the first to demonstrate the possibility of forming functionally active hybrid ribosomes from ribosomal subparticles of higher plants and mammals.
In 1978, in coordination with the M.A. Aitkhozhin by he transferred to work in the all-Russian research Institute of molecular biology Ministry of medical and microbiological industry of the USSR (Novosibirsk) for the development of methods of genetic engineering – new at the time, the direction of molecular biological research, where he formed the circle of his scientific interests that determined his whole further scientific activity. Under the leadership of A.Yu Beklemishev, in the all-Russian research Institute of molecular biology began work on the creation of a new generation of vaccines. The main scientific works during this period were devoted to the structural and functional study of the genomes of pathogenic viruses and the development of molecular vaccines and diagnostic drugs using modern methods of molecular biology and genetic engineering. In 1986, A.B. Beklemishev returned to Kazakhstan to head the laboratory of genetic engineering (LGI) at the new Institute of molecular biology and biochemistry, created by M.A. Aitkhozhin. The laboratory of genetic engineering (LGI) had more than 40 staff and included an immunology group headed by senior researcher N.N. Belyaev. The Director of the Institute M.A. Aitkhozhin set ambitious tasks for the laboratory to develop molecular vaccines of new generation, recombinant cytokines, as well as diagnostic test systems based on polymerase chain reaction and monoclonal antibodies for health care needs. The priority tasks of the study were to obtain a modified (non-toxic) staphylococcal alpha – toxin in recombinant form to create a molecular vaccine against staphylococcal infections, to obtain recombinant human cytokines-interleukin-1b and interleukin-3 for the creation of immunotherapeutic drugs, as well as to obtain monoclonal antibodies to staphylococcal alpha-toxin and enterotoxin A for the creation of enzyme diagnostic test systems. In this period under his leadership (jointly with N.N. Belyaev) produced two PhD theses (G.K. Zakiryanova and R.T. Tleulieva). During his work at the Institute (1986-1992) A.B. Beklemishev prepared a group of specialists in the field of molecular biology and genetic engineering. In 1992, due to family circumstances, he was forced to return to Novosibirsk, however, he continued to maintain scientific ties and participated in joint scientific work with scientists of the Republic of Kazakhstan. In particular, together with the staff of the laboratory of protein and nucleic acids IMBB he participated in the implementation of the project funded by the international Fund “INCO-Copernicus” (1999-2000), was a co-contractor on the project ISTC K-1482, carried out by the team of CFHM KazNU by al-Farabi (2005-2007), carried out joint research with the staff of CFHM and researchers of the biological faculty of KazNU by al-Farabi (2008-2009) on projects funded under the Program of cooperation in the field of science and technology between the Government of the Republic of Kazakhstan and the Government of the Russian Federation.
In 2004, A.B. Beklemishev defended his doctoral thesis on “the Use of molecular biology and genetic engineering methods for the design of vaccines and diagnostic drugs” in the field of “Biochemistry” and “Molecular biology”, and in 2010 he was awarded the title of Professor in the specialty “Molecular biology”. Currently, A.B. Beklemishev heads the laboratory of genetic engineering at the research Institute of biochemistry Siberian branch of the Russian Academy of medical Sciences (SB RAMS) (Novosibirsk). A.B. Beklemishev is the author of more than 230 scientific works, including one monograph and 13 inventions. Under his leadership, 8 PhD theses were completed and defended.