Scientists of the Laboratory of Structural and Functional Genomics of M.Aitkhozhin Institute of Molecular Biology and Biochemistry in the framework of the Project AP08857430 “Identification of a new minimally invasive biomarker for the diagnosis and prognosis of diabetic retinopathy based on microRNA” studied the hypothesis of the relationship between single nucleotide polymorphisms of the VEGF (-2549 I/D), RAGE (-429 T/C and -374 T/A) genes ), TCF7L2 (rs7903146) and ITGA2 (BglII+/-) with a predisposition to retinopathy among patients with type 2 diabetes mellitus in the Kazakh population.
The results of the study showed that the BglII+/- polymorphism of the ITGA2 gene may be associated with type 2 diabetes mellitus, but not with diabetic retinopathy. According to the data obtained, the risk for diabetes is the wild allele BglII-, and not the minor BglII+, which is considered as such for diabetic retinopathy.
This work was the result of a collaboration between our institute and scientists from S.D. Asfendiyarov Kazakh National Medicine University, al-Farabi Kazakh National University, Kazakhstan-Russian Medical University and the Center for the Treatment of Patients with Diabetes “AAA Medical Clinic”.
The researchers’ article was published in the peer-reviewed scientific journal MDPI “Medicina”.
Aizhan Magazova, Yeldar Ashirbekov, Arman Abaildayev, Kantemir Satken, Altynay Balmukhanova, Zhanay Akanov, Nurlan Jainakbayev, Aigul Balmukhanova, Kamalidin Sharipov